Endocrine Abstracts

Background: The use of high dose Ergot derived dopamine agonists in patients with Parkinson’s disease has been associated with an increased risk of cardiac valvular fibrosis. The UK Medicines and Health products Regulatory Agency (MHRA) currently advises baseline Echocardiogram within 3–6 months and follow up Echocardiogram at 6–12 monthly intervals in all patients taking ergot derived dopamine agonists. However, the risk of cardiac valvulopathy with lower doses...

We present a case of a 44-year-old chef, presenting with a fortnight’s history of a pruritic rash over his trunk and axillae. He was diagnosed to have hypertension, which was treated by lifestyle interventions. His diet was poor, and he drank 40 units of alcohol per week. His parents had hypercholesterolemia, but there was no history of premature coronary artery disease. On examination, his BMI was 31.62 kg/m2, and he had eruptive xanthomata on his chest, abdom...

Background: In our Hospital, we have noticed a large number of thyroid profile are being requested without any clinical suspicion, which has led to difficulty in interpretation of the results, dilemmas in subsequent management and an increment of inpatient Endocrine referrals.Objective and Aim: To evaluate our local practice in ordering thyroid function tests and to identify strategies to reduce unnecessary testing and i...

We report an unusual case of struma ovarii diagnosed after thyroidectomy for Graves’ disease and papillary thyroid cancer.A 46-year-old woman presented with a 3-month history of weight loss, palpitations and irregular periods. Physical examination revealed tachycardia, fine tremor and a diffuse goitre. TSH <0.1 (0.5–4.2 mU/l), FreeT4 26 (10.8–19.3 pmol/l) confirmed thyrotoxicosis.Thyroid ultrasound scan showed a ...

A secondary hypertension service was set up by the Endocrinology team in 2016 aiming to capture young hypertensive (age <30 years), refractory hypertension and hypertensive emergency to provide holistic care. A pathway was developed streaming Hypertensive emergencies to the high dependency area for intravenous treatment and hypertensive urgencies to the Ambulatory care for oral medications. All patients were linked to a secondary hypertension clinic. Staring with one clini...

Aims: Our aim was to explore predictive factors for the pleiotropic responses to exenatide during the first 12 weeks of therapy, and associations between these responses.Methods: This was an observational study based on patients (n=83) with type 2 diabetes mellitus (T2D) in whom exenatide had been added to existing oral hypoglycaemic therapy. Exenatide was administered subcutaneously (5 mcg bd for the first month, 10 mcg bd thereafter). Data colle...

Case history: A 38-year-old woman presented with blepharospasm, cramping of the hands, and paraesthesia primarily affecting the face and hands. Symptoms had been present for 10 years but had been progressive over the previous 12 months. Symptoms were consistent with neuromuscular instability. Hypocalcaemia and elevated Parathyroid hormone (PTH) were confirmed. Past medical history was notable for anorexia nervosa in remission. Family history was non-contributary. Hypocalcaemia...